Immunology/Microbiology Journal Club
GMS6921
Fall 2008
Thursday, 12:00-1:00
R2-265
Director: Dr. L.J. Chang (lchang@mgm.ufl.edu)

Recommended articles updated Oct. 20 (feel free to recommend one to Dr. Chang)


If you choose an article not on this list, please consult with Dr. Chang at least one week in advance.  Please keep in mind that the article should represent a whole new and exciting discovery - a paradigm shift in our understanding of immunity and/or microbiology - preferably a combination of the two fields - NOT an incremental addition to an ongoing story.  It should not be so focused in its scope that only a few members of the journal club will find it interesting.

Schedules from previous years with links to papers presented: 2004; 2005; 2006; 2007

Tips on preparing and delivering a good presentation.

Link to Anonymous Presentation Evaluation

University of Florida - EZProxy to Remotely Access Online Resources

Schedule

Date Presenter Critique* Article
8/28     Organizational Meeting
9/4 Daniel Perry Jennifer Joseph

"Bacterial entry to the splenic white pulp initiates antigen presentation to CD8(+) T cells". Immunity. 2008 Aug 27. Aoshi T, Zinselmeyer BH, Konjufca V, Lynch JN, Zhang X, Koide Y, Miller MJ.

9/11 Tolga Barker  

Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ.  ree in PMC  Mycobacterium tuberculosis Rv2224c modulates innate immune responses.  Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):264-9. Epub 2008 Jan 2.  (new article from originally posted)

9/18 Jason Weinstein Xinyi Wang
Immunity. 2008 Aug;29(2):306-17.  Gr1(+) Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen
Toxoplasma gondii.  Dunay IR, Damatta RA, Fux B, Presti R, Greco S, Colonna M, Sibley LD.
9/25 Sarah Guilmain Courtney Myhr

J Leukoc Biol. 2008 Jul;84(1):234-43. Epub 2008 Apr 9.  Adenylate cyclase toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells. Hickey FB, Brereton CF, Mills KH.

10/2 Sara Palmer Alex Cuenca

Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model.  Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7845-50. Epub 2008 May 28.  Gomes R, Teixeira C, Teixeira MJ, Oliveira F, Menezes MJ, Silva C, de Oliveira CI, Miranda JC, Elnaiem DE, Kamhawi S, Valenzuela JG, Brodskyn CI.

10/9 Ekta Patel Byung Ha Lee T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice.  Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, Laouar A, Yao J, Haridas V, Habiro K, Yang YG, Jeong JH, Lee KY, Kim YH, Kim SW, Peipp M, Fey GH, Manjunath N, Shultz LD, Lee SK, Shankar P.  Cell. 2008 Aug 22;134(4):577-86. Epub 2008 Aug 7.  
10/16 Cameron Lilly Yaima Luzarda
J Virol. 2008 Oct;82(20):9808-22. Epub 2008 Jul 30.  Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive
apoptosis in the peripheral blood during acute HCV infection and in the liver
during the chronic phase of infection.  Radziewicz H, Ibegbu CC, Hon H, Osborn MK, Obideen K, Wehbi M, Freeman GJ, Lennox
JL, Workowski KA, Hanson HL, Grakoui A.
10/23 Star Okada Abu M Nahid

Immunity, Vol 29, 650-659, 17 October 2008.  Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells.  CM Snyder, KS Cho, EL Bonnett, S van Dommelen, GR Shellam, and AB Hill

10/30 Jeanette Lo-Dauer Dennis Neeld Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells.   P.A. González, C.E. Prado, E.D. Leiva, L.J. Carreño, S.M. Bueno, C.A. Riedel, and A.M. Kalergis.   PNAS 105:14999-15004 published 25 September 2008
11/6 Sushrusha Nayak Steve Werden
J Immunol. 2008 Oct 15;181(8):5490-500.  T cell responses to whole SARS coronavirus in humans.  Li CK, Wu H, Yan H, Ma S, Wang L, Zhang M, Tang X, Temperton NJ, Weiss RA,
Brenchley JM, Douek DC, Mongkolsapaya J, Tran BH, Lin CL, Screaton GR, Hou JL, McMichael AJ, Xu XN.
11/13 Dana Catlfamo Kinda Seaton

A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections.  W Dejnirattisai, T Duangchinda, CS Lin, S Vasanawathana, M Jones, M Jacobs, P Malasit, X Xu, G Screaton, and J Mongkolsapaya.  J Immunol 2008 181: 5865-5874

11/20 Max Salganik Wilton Williams
J Virol. 2008 Dec;82(23):11637-50. Epub 2008 Sep 24.  The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance
priming of CD8 T cells by preventing negative feedback regulation.  Böhm V, Simon CO, Podlech J, Seckert CK, Gendig D, Deegen P, Gillert-Marien D,
Lemmermann NA, Holtappels R, Reddehase MJ.
11/27 Thanksgiving Holiday    
12/4 Sangani Rajnikumar Candace Bichsel

"Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function".  PNAS, Sep 9, 2008.  Vol. 105, No. 36, 13532-13537

12/11 11:00-1:00 First Year Students   Reports from First Lab Rotations.  
Pizza will be provided.

*A student will be paired with the senior presenting student to critique the presentation and PowerPoint BEFORE the journal club.  Please submit the critique with your name (not optional) by Friday afternoon of the journal club presentation.